Top 5 Enzymatic Cleaners for Cat Urine

Cat urine is one of the toughest stain that you wouldn’t want to face. The sticky yellow stain will not go away easily unless we apply serious bleaches on it.

And the smelly ammonia would take tons of deodorizer to get rid of.  Which is why the best enzyme cleaner for cat urine that we will show you now are the solution for the problem.

Enzyme cleaners don’t have chemical components that we often see on others stain remover products.

Instead, they contain thousands of bacteria that would produce different enzymes to get rid of the stains on your carpet, blanket, upholstery, and so on.

In this article we've outlined some very effective enzymatic cleaners, that you can use when cleaning cat urine as well as other stains. 

The Best Cat Urine Enzymatic Cleaners - Reviews

#1. Rocco and Roxie Stain and Odor Eliminator 

Rocco & Roxie Professional Strength Stain & Odor Eliminator
4.5 star

Editor's Rating: 4.7/5 Overall Score

The product can be applied on any types of stain, not only yellow cat urine spot but also food, coffee, and other stains. True to its name, this eliminator can even remove the toughest smells.

The secret of the effective performance is a deep-down formula that can access to the source of what is causing the smell and stains. It contains bacteria that will become extremely active when they contact with stains.

These bacteria will feed on the organic materials that cause the stains and odors  until they’re all gone. It’s also safe to use around children and pets. Besides, it can be utilized on many types of surface.

There is no doubt about the effectiveness of this product and I also love the mild lavender and mint smell. The only thing is that the price is a little high in comparison to other similar products. And for those who claim that the product isn’t working, it’s probably because they haven’t waited long enough for the bacteria to finish their job.


  • Effective with lots of cat stains
  • Nice and easy mint and lavender smell
  • Works well with most materials
  • Safe formula, even around pets and children


  • More expensive than similar removers

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#2. Nature's Miracle Urine Destroyer - Urine Enzymatic Formula

Nature's Miracle Urine Destroyer - Urine Enzymatic Formula
4.6 star

Editor's Rating: 4.6/5 Overall Score

Nature's Miracle has developed a "Urine Destroyer" which combats urine and the yellow sticky residue. The cleaner has an enzymatic formula, which is bacteria-based to produce enzymes when they come into contact with a food source: urine, feces, vomit and other pet bio-based messes.

The enzymatic cleaner will continue to work and destroy the stains until nothing is left behind. It destroys odors and discourages resoiling, so after you're done cleaning you won't see any stains or smell any bad odors. There will be a light fresh scent left.

This product works on variety of surfaces, you can use it on your carpet, as well as other fabrics like: leather, silk, suede and wool. As well as hardwood, linoleum, and tile.

This means that if your cat has accidentally urinated on the couch, armchair or your bed for example, you can safely use the cleaner in those areas too.


  • Enzymatic formula, works on different cat stains
  • Has light fresh scent
  • Destroys odor and the yellow urine stain
  • Works on variety of surfaces: carpets, furniture, hardwood, tile, and more


  • Doesn't come in a spray bottle

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#3. Pet Stain & Odor Miracle - Enzyme Cleaner for Dog and Cat Urine, Feces, Vomit, Drool

Pet Stain & Odor Miracle - Enzyme Cleaner for Dog and Cat Urine, Feces, Vomit, Drool
4.5 star

Editor's Rating: 4.5/5 Overall Score

There are many reasons why pet owners use and recommend this product. This is a powerful and natural formula, with natural enzymes which effectively remove cat or dog stains and odors, such as: urine, feces, vomit & drool.

It's made in the USA and is a safe way to clean your home and to use with kids and pets in the house. Works on multi-surfaces: carpet, hardwood, leather, rugs, etc.
You can buy it in two scents: spring mint and fall spice. You can get it in two sizes: 32 fl oz spray bottle or 1 gallon bottle

The company Sunny & Honey donates 10% of their profits to animal rescues and shelters. Also the company stands by and guarantees the results of this product in eliminating stains and odors, or they'll refund your money back.


  • Effective enzymatic cleaner
  • Works on variety of surfaces
  • Available in two scents: fresh mint or fall spice
  • Helps prevent repeat markings


  • Some users don't like the smell of the cleaner

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#4. Simple Solution Oxy Charged Pet Stain and Odor Remover

Simple Solution Oxy Charged Stain and Odor Remover
4.5 star

Editor's Rating: 4.4/5 Overall Score

This is a must-have remover for dealing with pet stains, common ones like poop, urine, vomit, and blood. The Triple-Oxy formula will quickly eliminate these stains and neutralize the smell.

You just need to apply it onto the surface and leave it until it’s air-dried. Also, the non-pet odor will prevent your kitten from re-soiling the area. The remover can be used on different types of material such as upholstery, carpet, wooden floor and likewise.

Plus, it’s safe to use near children and pets. You just need to avoid the liquid from touching sensitive parts like eyes or mouth.

The remover has a mild fragrance that might not be suitable to clean large areas that have been badly affected with bad odor. It’ll take days for the smell to go away and during that time, the smell will become a mix of disaster. It’s best to use it with small spots.


  • Great for cleaning small spots
  • Effective with all kinds of pet waste like cat pee, vomit, and poop
  • Prevent re-soiling or re-marking


  • Not suitable for cleaning large areas

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#5. Angry Orange Pet Odor Eliminator

Angry Orange Pet Odor Eliminator enzymatic cleaner for cat urine

Editor's Rating: 4.4/5 Overall Score

This eliminator is not for stains removing, but if you’re looking for something to get rid of the bad odor coming from your cat urine, this is perfect for the job.

Angry Orange’s formula is originated from an industrial odor eliminator that was used for poultry farms, slaughterhouses, and kennels. Which is why there is no surprise that it can work well at many different types of odor. The formula contains mostly derived oils of orange peels so it’s safe to smell, even for children and pets.

Moreover, you can take advantage of it on large areas like yard, hallway, laundry room. This will get rid of the urine smell and prevent your cat from re-marking the spot. The lack of stain removing feature is the biggest con for this product. Other than that, it’s perfect for eliminating bad odors.


  • Great orange smell
  • Effective formula for even the toughest smell
  • Safe to use because of the natural components
  • Can be used on large area


  • Lack of stain removing feature

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Other Things to Consider:

Stain size and type

What type of stain that you’re going to apply the product on? If it’s only cat urine, you should buy a specific cleaner for removing cat urine. And if you want a multi-purpose remover, that will work on stains and odors like: pee, poop and vomit, choose one that can be used on various stains and surfaces.

Personal interest

Choose a cleaner with a nice smell that suits you and your pets. Remember we’re not only cleaning the stains and getting rid of the bad odor. A nice scent is also a considerable factor.

Get a Cat Litter Mat

If you have noticed that your cat or kitten is usually making small urine drops on the floor next to it's litter box, a perfect solution to this problem would be to get a litter mat.

Check out our article on the best cat litter mats, so you can compare different brands and their features.

You'll be able to find a variety of sizes, and in addition you can find waterproof mats which won't let any liquids seep through and stain the area under the mat. Plus most of them are very easy to clean and can be washed. 

Another benefit of having a litter mat, is that it tracks litter very well inside, and won't let it scatter on the floor throughout your house. Which means you don't have to spend a lot of time cleaning and vacuuming.

Some cat owners also complain that their litter box has a very bad odor. One way to solve this is to change the cat litter, and find one that locks in odors and controls the bad smells. Another useful this is to change your litter box, and get a stainless steel litter box, which prevents the built up of bacteria inside and is very hygienic. 

enzymatic cleaner for cat urine


How to use an enzymatic cleaner?

Follow my guide to receive the best result when using stain remover and cleaner. First, use a tower to grab all the excessive wastes.

Apply the remover directly on the stains and wait for about 5-10 minutes depending on the condition. See if the stains are gone and leave it until air-dried.

What if the smell hasn’t gone after the process?

Apply the same or different enzymatic cleaner on the spot and wait until it’s air-dried. You can also leave it to expose to the sunlight. It’s a simple way but very effective.

You can also use baking soda as an odor remover if you see any cat pee on the floor. After you've used an enzymatic cleaner and cleaned up the stain, you can use baking soda by sprinkling some on the affected area.

Wait for a few minutes and then vacuum the area. Baking soda is a very good odor remover, and you should always have some at home if you want to achieve best results when cleaning. 

What makes enzyme cleaner safer compared to others?

An enzymes cleaner is mostly made with a bacterial-based formula which uses bacteria to generate enzymes that can destroy all the organic matter in the stains (such as: cat pee, vomit, feces, and drool).

There is often no chemical composition in the product. Hence, cleaners with enzymes are safe to smell and expose to bare skin. Just make sure that you don’t have any scratches on your skin.

Bottom line

The top-rated enzyme cleaners for cat urine which we’ve shown you are all the top-choice in their own category. Our number one recommendation is the Rocco and Roxie Stain and Odor Eliminator, which completely removes cat urine and any other organic cat stains it comes across. It comes in a very convenient spray bottle, so you can easily apply this enzymatic cleaner on any cat stains and odors you find.

You can also check out the other products on this list, and you're sure to find the best one for your needs. Whether it is deodorizing or stain removing, the most important is choosing the one that matches your preferences.

What type of stains do you want to clean? The surface you’re applying it on? And how would you like the cleaner to smell? These are the factors that you should focus on. 

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